#135 Laboratory for the development of chelators and their conjugates with vector molecules for the production of radiopharmaceuticals (LCC)

Laboratory employees

Zubenko Anastasia Dmitrievna	head of the laboratory, senior researcher, Ph.D.
Fedorov Yuri Viktorovich	leading researcher, Ph.D.
Tokarev Sergey Dmitrievich	senior researcher, Ph.D.
Egorova Bayirta Vladimirovna	senior researcher, Ph.D.
Matazova Ekaterina Viktorovna	senior researcher, Ph.D.
Shchukina Anna Alekseevna	junior researcher, Ph.D.
Pashanova Anna Vyacheslavovna	junior researcher, graduate student
Botezatu Anatoly	junior researcher, graduate student
Ikonnikova Irina Sergeevna	junior researcher, graduate student
Tarasenko Oksana Vladimirovna	research engineer, graduate student
Menshikov Mikhail Andreevich	research engineer, graduate student
Mosaleva Sofya Pavlovna	senior laboratory assistant, student
Alekseev Roman Ruslanovich	senior laboratory assistant, student
Kharkovskaya Daria Sergeevna	senior laboratory assistant, student

 

Historical reference

Laboratory for the development of chelators and their conjugates with vector molecules for the production of radiopharmaceuticals #135 under the guidance of Ph.D. Anastasia Dmitrievna Zubenko was established on November 7, 2022 as part of the national project “Science and Universities”. Previously, some of the staff members of the youth laboratory #135 were engaged in research on crown compounds as chelating agents for cations of heavy metals and radionuclides, as part of the Laboratory of photoactive supramolecular systems #107.

 

Research topics

Laboratory #135 engages in the synthesis of chelators of macrocyclic and acyclic structure, as well as comprehensive studies of their complexation properties with metal cations for medical applications in order to create diagnostic and therapeutic radiopharmaceuticals. For targeted delivery of a radionuclide complex to the affected area, bifunctional chelating agents and their conjugates with vector molecules, such as peptides, antibodies and nanoparticles, are being developed. Our research involves an integrated approach to solving the problem, from designing chelator structure to developing methods for their synthesis and a comprehensive analysis of their characteristics. For this, we use methods HPLC, mass spectrometry, NMR spectroscopy, X-ray diffraction analysis, quantum chemical calculations, potentiometric and spectrophotometric titration, as well as radionuclide labeling, and in vitro and in vivo stability assays. In the course of research, we determine the advantages and disadvantages of new ligands and identify patterns that influence their ability to bind to a particular metal cation. The results obtained make it possible to expand the range of potential new radiopharmaceuticals for the diagnosis and treatment of oncological diseases, which is currently highly relevant.

 

Scientific projects

• RSF 23-13-00424 “Low molecular conjugates for radionuclide diagnostics and therapy of oncological diseases”, leader Yuri Viktorovich Fedorov
• RSF 23-73-01270 “New N,O-containing crown compounds and their complexes with medical radionuclides”, leader Anastasia Dmitrievna Zubenko

 

Main publications for 2022-2024

1. Zubenko A.D., Shchukina A.A., Chernikova E.Y., Egorova B.V., Ikonnikova I.S., Priselkova A.B., Larenkov A.A., Bubenshchikov V.B., Mitrofanov A.A., Fedorov Y.V., Fedorova O.A. Synthesis of new acyclic chelators H₄aPyta and H₆aPyha and their complexes with Cu²⁺, Ga³⁺, Y³⁺, and Bi³⁺ // Dalton Transactions. – 2024. – Vol. 53. – P. 1141 - 1155.
2. Shchukina A.A., Zubenko A.D., Fedorova O.A. A novel method for the synthesis of acyclic ligands with combined chelating groups // Tetrahedron. – 2024. – Vol. 150. – P. 133773.
3. Shchukina A.A., Zubenko A.D., Karnoukhova V.A., Fedorov Y.V., Fedorova O.A. A New pyridine-azacrown compound py3am and crystal structures of its complexes with Zn²⁺ and Ni²⁺ cations // Journal of Structural Chemistry. – 2024. – Vol. 65(3). – P. 561-573.
4. Matazova E.V., Egorova B.V., Zubenko A.D., Pashanova A.V., Mitrofanov A.A., Fedorova O.A., Ermolaev S.V., Vasiliev A.N., Kalmykov S.N. Insights into actinium complexes with tetraacetates ─ AcBATA versus AcDOTA: thermodynamic, structural, and labeling properties // Inorganic Chemistry. – Vol. 62(31). – P. 12223-12236.
5. Zamurueva L.S., Egorova B.V., Ikonnikova I.S., Zubenko A.D., Pashanova A.V., Karnoukhova V.A., Mitrofanov A.A., Trigub A.L., Moiseeva A.A., Priselkova A.B., Fedorova O.A., Kalmykov S.N. Effect of the type of N-substituent in the benzo-18-azacrown-6 compound on copper(II) chelation: complexation, radiolabeling, stability in vitro, and biodistribution in vivo // Dalton Transactions. - 2023. – Vol. 52. – P. 8092–8106.
6. Khabirova S., Aleshin G., Anokhin E., Shchukina A., Zubenko A., Fedorova O., Averin A., Trusov L., Kalmykov S. Novel candidate theranostic radiopharmaceutical based on strontium hexaferrite nanoparticles conjugated with azacrown ligand // Dalton Transactions. - 2023. – Vol. 52. – P. 1731-1741.
7. Khabirova S., Aleshin G., Plakhova T., Zubenko A., Shchukina A., Fedorova O., Averin A., Belova E., Bazarkina E., Kvashnina K., Kalmkov S. CeO₂-azacrown conjugate as a nanoplatform for combined radiopharmaceuticals // Nanomaterials. – 2022. - Vol. 12(24). – P. 4484.
8. Matazova E.V., Egorova B.V., Zubenko A.D., Pashanova A.V., Fedorova O.A., Kalmykov S.N. Thermodynamic and kinetic features of Bi³⁺ complexes with the azamacrocycles H₄BATA and H₄DOTA // ChemistrySelect. — 2022. — Vol. 7, no. 44. — P. e202203108.
9. Egorova B.V., Zamurueva L.S., Zubenko A.D., Pashanova A.V., Mitrofanov A.A., Priselkova A.B., Fedorov Y.V., Trigub A.L., Fedorova O.A., Kalmykov S.N. Novel hybrid benzoazacrown ligand as a chelator for copper and lead cations: What difference does pyridine make // Molecules. – 2022. – Vol. 27(10). – P. 3115.

 

Contact details

Tel.: +7(499)135-9280 ext. 1119
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