In our work, we focus on chemistry of indoles, indoxyls, and fused indoles for subsequent development of new reactions and synthetic approaches towards biologically active compounds involving these functionalities.
In addition, we perform diversity-oriented synthesis of privileged scaffolds for development of new antituberculosis and psychotropic drugs.
Program of the Presidium of the RAS «Fundamental science to medicine». Coordinator: academician A.I.Grigor'ev.
A.R.Khokhlov «Synthesis of new drug, which is active against resistant strains of mycobacteria tuberculosis, and its dosage form». Program DCMS-09 (OHNM-09) «Medical and biomolecular chemistry». Coordinator: academician N.S.Zefirov.
A.R.Khokhlov «Development of new polymer carrier for therapeutic agents active against mycobacteria tuberculosis with multiple drug resistance».
V.S.Velezheva, A.I.Sokolov, A.G.Kornienko, K.A.Lyssenko, Y.V.Nelyubina, I.A.Godovikov, A.S.Peregudov, A.F.Mironov. The role of a Lewis acid in the Nenitzescu indole synthesis. Tetrahedron Lett., 2008, 49 (50), 7106-7109. DOI: 10.1016/j.tetlet.2008.09.087
V.S.Velezheva, V.N.Azev, A.G.Kornienko, A.S.Peregudov, I.A.Godovikov, Yu.L.Sebyakin. The stereoselective synthesis of highly functionalized tertiary 3-aminoindoles/anilines or dihydropyrroles from C-(3-indolyl)-N-aryl and C,N-diaryl nitrones. Tetrahedron Lett., 2010, 51 (50), 6594-6597. DOI: 10.1016/j.tetlet.2010.10.045